Anti-phospho-Cyclin E1 (pThr³⁹⁵) antibody produced in rabbit

The antibody detects endogenous level of Cyclin E1 only when phosphorylated at threonine 395.

Peptide sequence around phosphorylation site of threonine 395 (L-L-Tp-P-P), according to the protein NP_001229.1

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition.

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol