SAB3500178
Anti-LXR-A antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-LXRA, Anti-Liver X receptor A, Anti-NR1H3, Anti-Nuclear receptor subfamily 1 group H member 3
产品名称
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 44-49 kDa
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NR1H3(10062)
Biochem/physiol Actions
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
Immunogen
LXR-A antibody was raised against a 15 amino acid peptide from near the amino terminus human LXR-A.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500178.
Physical form
Supplied in PBS with 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Liver x receptors in atherosclerosis and inflammation.
Im SS and Osborne TF
Circulation Research, 108, 996-1001 (2011)
CCAR2 negatively regulates nuclear receptor LXRa by competing with SIRT1 deacetylase.
Sakurabashi A
The Journal of Steroid Biochemistry and Molecular Biology, 149, 80-88 (2015)
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