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R6520

Sigma-Aldrich

咯利普兰

≥98% (HPLC), solid, cAMP-specific phosphodiesterase (PDE4) inhibitor

别名:

4- [3-（环戊基氧基）-4-甲氧基苯基]-2-吡咯烷酮, ZK 62711

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About This Item

经验公式（希尔记法）:
C16H21NO3
CAS号:
61413-54-5
分子量:
275.34
EC 号:
262-771-1
MDL编号:
MFCD00270906
UNSPSC代码:
41106305
PubChem化学物质编号:
24278196
NACRES:
NA.77

product name

咯利普兰, solid, ≥98% (HPLC)

生物来源

synthetic (organic)

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

H2O: 0.2 mg/mL
ethanol: 7 mg/mL
DMSO: 7.3 mg/mL

SMILES字符串

COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3

InChI

1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChI key

HJORMJIFDVBMOB-UHFFFAOYSA-N

基因信息

human ... LITAF(9516) , PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE7A(5150)
mouse ... Pde4a(18577)
rat ... Adora1(29290) , Pde1b(29691) , Pde2a(81743) , Pde3a(50678) , Pde4a(25638) , Pde4b(24626) , Pde4c(290646) , Pde5a(171115)

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一般描述

咯利普兰增强组织保护、解剖修复和功能恢复。用于治疗哮喘、关节炎、亨廷顿氏（Huntington′s）病和多发性硬化症。 咯利普兰抑制损伤引起的环AMP减少，这种减少与急性中枢神经系统损伤有关。它起抗抑郁的作用，在髓磷脂抑制剂存在的情况下，刺激神经突生长和轴突再生。

应用

咯利普兰可用于：
  • 研究其对睾丸扭转-复位损伤的影响（36）
  • 阻断磷酸二酯酶-4（PDE4）的作用（37）
  • 作为化学性诱导长期增强（cLTP）诱导培养基的成分（38）

生化/生理作用

选择性 cAMP 特异性磷酸二酯酶 (PDE4) 抑制剂。

特点和优势

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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Raehannah J Jamshidi et al.
The Journal of pharmacology and experimental therapeutics, 359(2), 319-328 (2016-10-21)
A single administration of the κ opioid receptor (KOR) antagonist, norbinaltorphimine (norBNI), produces long-term reduction in KOR function in heterologous expression systems and brain that is mediated by activation of c-Jun N-terminal kinase (JNK). In this study, we examined the
Eva Bollen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(11), 2497-2505 (2014-05-13)
Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers
Ju-Ing Shao et al.
Journal of the Chinese Medical Association : JCMA, 82(7), 568-575 (2019-07-06)
Meconium aspiration syndrome (MAS) is a major cause of severe respiratory failure in near- and full-term neonates. Alleviating inflammation is key to successfully treating severe MAS. Phosphodiesterase (PDE) inhibitors are known to play a role in airway smooth muscle relaxation
Badar Mahmood et al.
BMC cancer, 16(1), 938-938 (2016-12-09)
Intracellular signaling through cyclic nucleotides, both cyclic AMP and cyclic GMP, is altered in colorectal cancer. Accordingly, it is hypothesized that an underlying mechanism for colorectal neoplasia involves altered function of phosphodiesterases (PDEs), which affects cyclic nucleotide degradation. Here we
CNS Regeneration: Basic Science and Clinical Advances (2011)
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