所有图片(3)
About This Item
经验公式（希尔记法）:
C13H22N4O3S · HCl
CAS号:
分子量:
350.86
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
形式
solid
质量水平
颜色
tan
溶解性
H2O: 1.8 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
创始人
GlaxoSmithKline
SMILES字符串
Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI
1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key
GGWBHVILAJZWKJ-CHHCPSLASA-N
基因信息
human ... HRH2(3274)
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应用
盐酸雷尼替丁已被用作开发和验证平行人工膜渗透性试验 (PAMPA) 的参考化合物。
生化/生理作用
雷尼替丁主要用于治疗非甾体类抗炎药 (NSAID) 引起的胃肠道损害。
H2 组胺受体拮抗剂；抗溃疡剂。
特点和优势
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ying Liu et al.
Molecular and cellular biochemistry, 448(1-2), 61-69 (2018-02-07)
Abnormal angiogenesis is critically involved in tumor progression and metastasis including endometrial cancer and is regulated by microRNAs such as microRNA-101 (miR-101). We hypothesize that miR-101 expression is disrupted in endometrial cancer and modulation of miR-101 levels is sufficient to
P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz [b, f] azepine-5-carboxamide derivatives
Fortuna A, et al.
Journal of Pharmaceutical Sciences, 101(2), 530-540 (2012)
Ruth Prieto-Montero et al.
Sensors (Basel, Switzerland), 20(19) (2020-10-03)
Functionalized fluorescent silica nanoparticles were designed and synthesized to selectively target cancer cells for bioimaging analysis. The synthesis method and characterization of functionalized fluorescent silica nanoparticles (50-60 nm), as well as internalization and subcellular localization in HeLa cells is reported
Ranitidine
Grant S M, et al.
Drugs, 37(6), 801-870 (1989)
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