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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous glycerol solution
分子量
antigen 53 kDa
种属反应性
mouse, human
技术
microarray: suitable
western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... TP53(7157)
mouse ... Trp53(22059)
一般描述
p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
特异性
Does not react with non-phosphorylated p53.
免疫原
synthetic peptide corresponding to residues around Ser392 of human p53 conjugated to KLH.
生化/生理作用
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
外形
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol
制备说明
Purified using protein A and peptide affinity chromatography.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Hong Chang
British Journal of Haematology, 127(3), 280?284-280?284 (2004)
Mutations in the p53 Tumor Suppressor Gene
Noa Rivlin
Genes & Cancer, 2(4), 466?474-466?474 (2011)
Suppression of p53 potentiates chemosensitivity in nutrient?deprived cholangiocarcinoma cells via inhibition of autophagy
Fei Hui
Oncology, 14.2, 1959-1966 (2017)
商品
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
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