形式
solid
质量水平
颜色
white
溶解性
H2O: ≥43 mg/mL, colorless to almost colorless
创始人
Sanofi Aventis
SMILES字符串
CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
InChI key
MQGNNJQTNFHNHK-UHFFFAOYSA-N
基因信息
human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124)
rat ... Tnf(24835)
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应用
Pentoxifylline has been used:
- used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
- to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
- to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
生化/生理作用
Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Lact.
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Naranjo T W, et al.
Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)
PP-023-Effect of ICSI with `pentoxifylline exposed sperms? on subsequent embryo development
Mangoli V S, et al.
Reproductive Biomedicine Online, 32, S11-S11 (2016)
B K Reuter et al.
The American journal of physiology, 277(4 Pt 1), G847-G854 (1999-10-12)
Although the ability of nonsteriodal anti-inflammatory drugs (NSAIDs) to injure the small intestine has been well established in humans and animals, the mechanism involved in this type of injury has yet to be elucidated. The cytokine tumor necrosis factor-alpha (TNF-alpha)
Pentoxifylline in the Treatment of Cutaneous Leishmaniasis: A Randomized Clinical Trial in Colombia.
Maria Del Mar Castro et al.
Pathogens (Basel, Switzerland), 11(3) (2022-03-27)
Addition of the immunomodulator pentoxifylline (PTX) to antimonial treatment of mucosal leishmaniasis has shown increased efficacy. This randomized, double-blind, placebo-controlled trial evaluated whether addition of pentoxifylline to meglumine antimoniate (MA) treatment improves therapeutic response in cutaneous leishmaniasis (CL) patients. Seventy-three
Saad Hamama et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(3), 305-312 (2012-10-02)
Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. Ten patients suffering from radiation-induced enteropathy
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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