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重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
564-764 nmol/min·mg
分子量
~98 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PRKCI(5584)
一般描述
PKCι (protein kinase C ι) belongs to the protein kinase C family.
生化/生理作用
Protein kinase C ι (PKCι) is involved in Ras signaling. In colonic epithelium, it is an important regulator of oncogenic Ras. Transgenic mice which are constitutively expressing PKCι are at high risk of carcinogen-mediated colon carcinogenesis.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Nicole R Murray et al.
The Journal of cell biology, 164(6), 797-802 (2004-03-17)
Protein kinase C iota (PKCiota) has been implicated in Ras signaling, however, a role for PKCiota in oncogenic Ras-mediated transformation has not been established. Here, we show that PKCiota is a critical downstream effector of oncogenic Ras in the colonic
J Rennecke et al.
European journal of biochemistry, 242(2), 428-432 (1996-12-01)
13 murine tissues and 12 cell lines were tested for the expression of the novel protein kinase C (PKC) isoenzyme mu. Using two different PKC mu antibodies (sc-639 and P26720), PKC mu was detected in all tissues and cells and
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