I6658
Isradipine
≥98% (HPLC), calcium channel blocker, solid
别名:
4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C19H21N3O5
化学文摘社编号:
分子量:
371.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Isradipine, ≥98% (HPLC), solid
SMILES string
COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C
InChI key
HMJIYCCIJYRONP-UHFFFAOYSA-N
InChI
1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
description
Store under nitrogen
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: >10 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781)
正在寻找类似产品? 访问 产品对比指南
Application
Isradipine has been used to explore neuroprotective activity.
Biochem/physiol Actions
Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
L-type calcium channel blocker; antihypertensive.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Thimmappa S Anekonda et al.
Neurobiology of disease, 41(1), 62-70 (2010-09-08)
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility
Dalton James Surmeier et al.
Antioxidants & redox signaling, 14(7), 1289-1301 (2010-08-18)
Parkinson's disease (PD) is a major world-wide health problem afflicting millions of the aged population. Factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated public discussions of disease etiology. Although
Fernando A Aguiar et al.
Electrophoresis, 32(19), 2673-2682 (2011-10-11)
A simple enantioselective method based on CE using CD as chiral selector was developed and validated for the determination of isradipine (IRD) enantiomers in a pharmaceutical formulation and for the determination of IRD enantiomers in degradation studies. After optimization, the
Vincent Malaterre et al.
International journal of pharmaceutics, 376(1-2), 56-62 (2009-04-23)
Despite more than 30 years of clinical use, only few studies have been published reporting on the release mechanism underlying the drug delivery from push-pull osmotic pumps (PPOP). The aim of this study is to understand which factors have an
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.
E Ilijic et al.
Neurobiology of disease, 43(2), 364-371 (2011-04-26)
The motor symptoms of Parkinson's disease (PD) are due to the progressive loss of dopamine (DA) neurons in substantia nigra pars compacta (SNc). Nothing is known to slow the progression of the disease, making the identification of potential neuroprotective agents
相关内容
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持