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Merck
CN

H7250

Sigma-Aldrich

组胺 二盐酸盐

≥99% (TLC), powder, endogenous histamine receptor agonist

别名:

2-(4-咪唑)乙胺 二盐酸盐

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About This Item

经验公式(希尔记法):
C5H9N3 · 2HCl
CAS号:
分子量:
184.07
Beilstein:
3624116
EC 号:
MDL编号:
UNSPSC代码:
12352116
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.77

产品名称

组胺 二盐酸盐, ≥99% (TLC), powder

质量水平

方案

≥99% (TLC)

表单

powder

颜色

white to off-white

mp

249-252 °C (lit.)

储存温度

2-8°C

SMILES字符串

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

基因信息

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一般描述

盐酸组胺是一种组胺衍生物。它能阻止ROS(活性氧)形成,后者可抑制T细胞和自然杀伤细胞的活化。盐酸组胺与肿瘤细胞凋亡有关。它可以预防急性髓性白血病患者的复发。

应用

组胺二盐酸盐已用于以下情形:
  • 作为正交变共递质,用于产生兴奋性突触后电位(EPSP)
  • 使用 HPLC(高效液相色谱法)测定在鱼体内的水平
  • 评估豚鼠对抗原的气管反应

生化/生理作用

内源性 H1 和 H2 组胺受体激动剂;可活化一氧化氮合成酶;有效的血管舒张剂。

特点和优势

《受体分类和信号转导》手册的 组胺受体 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物是神经科学研究推荐产品。点击此处 ,查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

象形图

Health hazardExclamation mark

警示用语:

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. How should Product H7250, Histamine dihydrochloride, be dissolved?

    We test the solubility of this product in water at a concentration of 50 mg/mL. This yields a clear, colorless to faint yellow solution.

  7. How should Product H7250, Histamine dihydrochloride, be stored?

    This product is a powder and should be stored at 2-8°C, dessicated.

  8. What is the solution stablity of Product H7250, Histamine dihydrochloride?

    Solutions can be stored at 2-4°C for 8 weeks, and at -20°C for up to 12 months. Once thawed, solutions should be used within 6 hours or discarded. Solutions are light sensitive and need to be protected from light.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation (2013)
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
Nitric oxide as an orthograde cotransmitter at central synapses of Aplysia: responses of isolated neurons in culture
Jacklet JW and Koh HY
American Zoologist, 41(2), 282-291 (2001)
Maternal dietary antigens and the immune response in the offspring of the guinea-pig.
Telemo E, et al.
Immunology, 62(1), 35-35 (1987)

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