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质量水平
mp
282-285 °C (dec.)
SMILES字符串
[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI
1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key
FAPSXSAPXXJTOU-UHFFFAOYSA-L
基因信息
human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)
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应用
溴化六甲铵已用于：
- 作为自主神经节阻断剂，研究其对大鼠胡须运动的影响
- 作为烟碱受体拮抗剂，研究其对小鼠抗原诱导关节炎(AIA)进展的影响
- 作为非选择性神经节烟碱型乙酰胆碱受体(nAChR)拮抗剂，研究其对小鼠中金雀花碱诱导的自主心血管反应的影响
生化/生理作用
溴化六甲铵是针对烟碱型乙酰胆碱受体(nAChR)的拮抗剂。它优先阻断自主神经节上的烟碱受体，只有在高剂量时才能穿过血脑屏障。
特点和优势
该化合物在《受体分类和信号转导手册》的 乙酰胆碱受体（烟酸） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Piyali Dasgupta et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(16), 6332-6337 (2006-04-08)
Non-small cell lung cancer (NSCLC) demonstrates a strong etiologic association with smoking. Although nicotine is not carcinogenic, it can induce cell proliferation and angiogenesis and suppress apoptosis induced by certain agents. Here we show that nicotine inhibits apoptosis induced by
James T Heaton et al.
Neuroscience, 265, 9-20 (2014-02-01)
Vibrissal whisking is often employed to track facial nerve regeneration in rats; however, we have observed similar degrees of whisking recovery after facial nerve transection with or without repair. We hypothesized that the source of non-facial nerve-mediated whisker movement after
Alexandre Kanashiro et al.
Basic & clinical pharmacology & toxicology, 119(5), 453-457 (2016-04-22)
The cholinergic anti-inflammatory pathway (CAP) is a complex neuroimmune mechanism triggered by the central nervous system to regulate peripheral inflammatory responses. Understanding the role of CAP in the pathogenesis of rheumatoid arthritis (RA) could help develop new therapeutic strategies for
Simon Akerman et al.
Brain : a journal of neurology, 135(Pt 12), 3664-3675 (2012-10-16)
Trigeminal autonomic cephalalgias are highly disabling primary headache disorders, characterized by severe unilateral head pain and associated ipsilateral cranial autonomic features. There is limited understanding of their pathophysiology and how and where treatments act to reduce symptoms; this is significantly
Kamila Shakarchi et al.
The Journal of experimental biology, 216(Pt 5), 869-880 (2012-11-17)
The chemosensory roles of gill neuroepithelial cells (NECs) in mediating the hyperventilatory response to hypoxia are not clearly defined in fish. While serotonin (5-HT) is the predominant neurotransmitter in O(2)-sensitive gill NECs, acetylcholine (ACh) plays a more prominent role in
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