H0879
溴化已烷双胺
nAChR antagonist
别名:
N,N,N,N′,N′,N′-六甲基六亚甲基二溴铵, 己烷-1,6-双（三甲基溴化铵）
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关于此项目
线性分子式:
(CH3)3N(Br)(CH2)6N(Br)(CH3)3
化学文摘社编号:
分子量:
362.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-249-7
MDL number:
Beilstein/REAXYS Number:
3715749
Quality level:
产品名称
溴化已烷双胺,
InChI
1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key
FAPSXSAPXXJTOU-UHFFFAOYSA-L
SMILES string
[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C
mp
282-285 °C (dec.)
Quality Level
Gene Information
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相关类别
Application
溴化六甲铵已用于：
- 作为自主神经节阻断剂，研究其对大鼠胡须运动的影响
- 作为烟碱受体拮抗剂，研究其对小鼠抗原诱导关节炎(AIA)进展的影响
- 作为非选择性神经节烟碱型乙酰胆碱受体(nAChR)拮抗剂，研究其对小鼠中金雀花碱诱导的自主心血管反应的影响
Biochem/physiol Actions
溴化六甲铵是针对烟碱型乙酰胆碱受体(nAChR)的拮抗剂。它优先阻断自主神经节上的烟碱受体，只有在高剂量时才能穿过血脑屏障。
Features and Benefits
该化合物在《受体分类和信号转导手册》的 乙酰胆碱受体（烟酸） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Previous studies suggest that ANG II-induced hypertension in rats fed a high-salt (HS) diet (ANG II-salt hypertension) has a neurogenic component dependent on an enhanced sympathetic tone to the splanchnic veins and independent from changes in sympathetic nerve activity to
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Among enterovirus 71 infections, brainstem encephalitis progressing abruptly to cardiac dysfunction and pulmonary edema causes rapid death within several hours. However, no currently known early indicators and treatments can monitor or prevent the unexpectedly fulminant course. We investigate the possible
Kamila Shakarchi et al.
The Journal of experimental biology, 216(Pt 5), 869-880 (2012-11-17)
The chemosensory roles of gill neuroepithelial cells (NECs) in mediating the hyperventilatory response to hypoxia are not clearly defined in fish. While serotonin (5-HT) is the predominant neurotransmitter in O(2)-sensitive gill NECs, acetylcholine (ACh) plays a more prominent role in
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International journal of oral science, 4(1), 24-29 (2012-03-06)
Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses; however, the effects of anesthesia with pentobarbital sodium on these responses are unclear. Pentobarbital sodium was infused intravenously at a nominal rate and the lingual nerve was electrically
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