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质量水平
检测方案
≥99% (TLC)
形式
powder
技术
ligand binding assay: suitable
颜色
white to off-white
mp
200-202 °C (subl.) (lit.)
SMILES字符串
N[C@H](CCC(O)=O)C(O)=O
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChI key
WHUUTDBJXJRKMK-GSVOUGTGSA-N
基因信息
human ... CCR2(1231)
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一般描述
D-谷氨酸是细菌肽聚糖结构的必需成分。可通过D-谷氨酸添加酶（murD）将其加入UDP-N-乙酰胞壁酰-L-丙氨酸（UDP-MurNAc-L-丙氨酸）中。然后将其掺入肽聚糖前体中。 肽聚糖构成革兰氏阳性和阴性细菌的细胞壁。通过谷氨酸消旋酶（GR）将L-谷氨酸转化为D-谷氨酸是肽聚糖合成中必不可少的步骤。
应用
D-谷氨酸适用于GR酶（谷氨酸消旋酶）及其抑制剂的结构亲和关系（SAR）研究。
生化/生理作用
谷氨酸的非天然异构体。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Matthew Volgraf et al.
Nature chemical biology, 2(1), 47-52 (2006-01-13)
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We
P Doublet et al.
Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)
The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by
Katie L Whalen et al.
Molecular informatics, 30(5), 459-471 (2011-07-09)
Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a
Dimitri Ryczko et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(17), E2440-E2449 (2016-04-14)
Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive
Jia Luo et al.
Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)
The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we
Chromatograms
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