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F6892

法尼焦磷酸铵盐

Name: 法尼焦磷酸 铵盐
Brand: SIGMA

methanol:ammonia solution, ≥95% (TLC)

别名:

3,7,11-三甲基-2,6,10-十二碳三烯-1-基焦磷酸铵盐, FPP

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关于此项目

经验公式（希尔记法）:

C₁₅H₃₇N₃O₇P₂

化学文摘社编号:

13058-04-3

分子量:

433.42

NACRES:

NA.83

PubChem Substance ID:

24894923

UNSPSC Code:

12352204

MDL number:

MFCD00189688

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属性

Quality Level

100

assay

≥95% (TLC)

form

methanol:ammonia solution

packaging

vial of 200 μg

storage temp.

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+

InChI key

VWFJDQUYCIWHTN-YFVJMOTDSA-N

Gene Information

rat ... Fnta(25318)

说明

General description

法尼基焦磷酸是由15碳组成的类异戊二烯，在法尼基焦磷酸合成酶（FPPS）的作用下由牻牛儿焦磷酸（GPP）合成。

Application

法尼基焦磷酸铵盐用于：

用作人成骨肉瘤细胞的异戊二烯化激动剂，用于基于胶原的细胞侵袭试验
人脐静脉内皮细胞（HUVECs）中肝细胞生长因子（HGF）的异戊二烯化
用作底物，用于硅藻（Haslea ostrearia）异戊二烯基转移酶测定。

Biochem/physiol Actions

法尼基焦磷酸（FPP）是生物合成胆固醇、泛醌和多萜醇的前体。是细胞内甲羟戊酸途径的一部分。FPP是细胞存活所必需的物质，用于某些低分子质量G蛋白（含Ras）的异戊二烯化。抑制异戊二烯化可造成Ras蛋白丧失致癌潜能。抑制异戊二烯化具有治疗潜力，或可用于突触可塑性和阿尔兹海默′病的治疗。

Physical form

甲醇溶液：10mM水溶性NH₄OH (7:3)
实际浓度见标签

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H315,H319,H370,H412

pcodes

P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

60.8 °F

flash_point_c

16 °C

法规信息

危险化学品

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商品

Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

胆固醇生物合成

胆固醇的生物合成通常发生在肝细胞的内质网中，并以乙酰辅酶A开始，乙酰辅酶A主要来源于线粒体中的氧化反应。乙酰辅酶A和乙酰乙酰辅酶A由HMG-辅酶A合成酶转化为3-羟基-3-甲基戊二酰辅酶A（HMG-辅酶A）。

Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative.

Petra M Bleeker et al.

Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20124-20129 (2012-11-22)

Tomato breeding has been tremendously efficient in increasing fruit quality and quantity but did not focus on improving herbivore resistance. The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with

Isoprenoid biosynthesis in the diatom Haslea ostrearia

Kampranis SC and Verret F

The New phytologist, 1-1 (2018)

Using Game Theory to Understand Systemic Acquired Resistance as a Bet-Hedging Option for Increasing Fitness When Disease Is Uncertain.

Gregory J Reynolds et al.

Plants (Basel, Switzerland), 8(7) (2019-07-25)

Systemic acquired resistance (SAR) is a mechanism through which plants may respond to initial challenge by a pathogen through activation of inducible defense responses, thereby increasing resistance to subsequent infection attempts. Fitness costs are assumed to be incurred by plants

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全球贸易项目编号

货号	GTIN
F6892-5VL	04061833619131
F6892-1VL	04061833619124

主要文件

法尼焦磷酸铵盐

methanol:ammonia solution, ≥95% (TLC)