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Dear Customer:

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If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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CHOGS

SAFC

CHOZN® GS-/- ZFN-改良 CHO 细胞系

别名:

CHOZN ® ZFN 修饰的 CHO 细胞系

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10 MG
¥939.00
50 MG
¥4,076.71

¥939.00

目录价¥1,276.30节省 26%

国内现货，预计发货时间2025年4月25日详情

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10 MG
¥939.00
50 MG
¥4,076.71

About This Item

UNSPSC代码:
12352200
NACRES:
NA.75

¥939.00

目录价¥1,276.30节省 26%

国内现货，预计发货时间2025年4月25日详情

描述

CHOZN® GS-/- ZFN-modified CHO cell line
glutamine synthetase knockout cell line

溶解性

DMSO: 5 mg/mL, clear

运输

liquid nitrogen

储存温度

−196°C

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PHR1394343290F918
Fluoxetine hydrochloride solid

F132

Fluoxetine hydrochloride

Fluoxetine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1394

Fluoxetine Hydrochloride

Fluoxetine, Hydrochloride A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).

343290

Fluoxetine, Hydrochloride

Fluoxetine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

F918

Fluoxetine hydrochloride solution

form

solid

form

-

form

solid

form

liquid

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

300

solubility

H2O: 4 mg/mL, DMSO: >5 mg/mL

solubility

-

solubility

methanol: 100 mg/mL, water: 5 mg/mL

solubility

-

originator

Eli Lilly

originator

-

originator

-

originator

-

color

white

color

-

color

-

color

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Gene Information

human ... SLC6A4(6532)

Gene Information

-

Gene Information

human ... SLC6A4(6532)

一般描述

ZFN 是一类工程 化的DNA 结合蛋白，可导致双链断裂。这种双链断裂是位点特异性诱变介导的 DNA 修复所必需的。它通过与用户指定的基因座结合来促进靶向基因组的编辑。[1]谷氨酰胺合成酶（GS）是生物制药行业中最常用的选择性标记之一。 谷氨酰胺是细胞生长的必需氨基酸。[2]GS酶负责将谷氨酸盐转化为谷氨酰胺。[3]没有这种酶活性的话，细胞不能再合成内源谷氨酰胺，如果培养基中不补充谷氨酰胺，细胞将死亡。
利用 Sigma ′CompoZr 锌指核酸酶 (ZFN) 专利技术创建 CHOZN 细胞系，在亲代 CHO-K1 细胞中创建遗传修饰。 细胞储存在化学成分明确、无动物成分的 EX-CELL CD CHO 融合培养基中

细胞系来源

CHOZN 细胞系均为 1957 年 Puck 创立的亲本 CHO-K1 细胞系的亚克隆。

包装

本产品采用液氮托运桶运输。
产品价格不包括液氮托运桶费用（最高 125 美元）和运费。
液氮托运桶并非一次性用品，应在收到后退回。如果在交货后 1 周内未退回，将收取 450 美元的液氮托运桶费用。
了解更多关于液氮托运桶的信息

外形

向客户提供含有 > 7.5e6 个细胞/mL 小瓶的 CHOZN 细胞系

法律信息

所有 CHOZN 细胞系均在 Sigma Aldrich 的许可下出售。 购买 CHOZN 细胞系时提供一份研究许可证副本。
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

动植物来源生物产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    2113-53667
    051M0924

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    Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
    DeBerardinis R J and Cheng T
    Oncogene, 29(3), 313-313 (2010)
    The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
    Yuneva M O, et al.
    Cell Metabolism, 15(2), 157-170 (2012)
    Cytotoxic effects during knock out of multiple porcine endogenous retrovirus (PERV) sequences in the pig genome by zinc finger nucleases (ZFN).
    Semaan M, et al.
    PLoS ONE, 10(4), e0122059-e0122059 (2015)

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    通过灌流式种子培养优化CHO细胞制备，以提高生产力

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