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Merck
CN
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文件

安全信息

C4382

Sigma-Aldrich

卡巴胆碱

≥98% (titration), crystalline

别名:

卡巴胆碱, 氯化氨甲酸胆碱, （2-羟乙基）三甲基氯化铵氨基甲酸酯

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About This Item

线性分子式:
NH2COOCH2CH2N(Cl)(CH3)3
CAS号:
51-83-2
分子量:
182.65
Beilstein:
3917459
EC 号:
200-127-3
MDL编号:
MFCD00012011
UNSPSC代码:
12352200
PubChem化学物质编号:
24277829
NACRES:
NA.77

质量水平

100

检测方案

≥98% (titration)

形式

crystalline

颜色

white

mp

210 °C (dec.) (lit.)

溶解性

H2O: 1 g/mL
ethanol: 20 mg/mL

SMILES字符串

[Cl-].C[N+](C)(C)CCOC(N)=O

InChI

1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H

InChI key

AIXAANGOTKPUOY-UHFFFAOYSA-N

基因信息

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA2(1135)
mouse ... Chrm1(12669)
rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Chrna2(170945) , Chrna3(25101) , Chrna4(25590)

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应用

在小鼠瞳孔对光反射的研究中，氯化氨基甲酰胆碱已被用于：
  • 刺激转基因小鼠的胰岛素分泌
  • 诱导未分化和分化的人脂肪干细胞 (hASCs) 收缩
  • 介导虹膜收缩

生化/生理作用

卡巴胆碱通过与毒蕈碱受体相互作用而引起泪液分泌。本品为乙酰胆碱的类似物，为抗青光眼药。在纤毛突起中，卡巴胆碱连同一氧化氮 (NO) 一起调节 Na + 和 K + -atp 酶活性。其刺激胰岛素囊泡转运至分泌站点以增加胰岛素分泌。
抗胆碱酯酶操作的非选择性胆碱能激动剂；抑制培养的神经元凋亡，并可能诱导胸腺细胞凋亡。

特点和优势

该化合物在《受体分类和信号转导》手册的 乙酰胆碱受体（烟碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 2 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

危险化学品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the difference between Carbamoylcholine chloride Products C4382 and C2409?

    C4382 (98%) and C2409 (99%) are the same chemical with slightly different purity specifications. Product No. C2409 is no longer available.

  4. How should Carbamoylcholine chloride, Product C4382, be dissolved?

    This product is soluble in water (1000 mg/mL), in ethanol (20 mg/mL), and in methanol (100 mg/mL).

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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