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Merck
CN
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安全信息

A8973

Sigma-Aldrich

2-花生四烯基甘油

~10 mg/mL, ≥98% (HPLC)

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别名:
2-AG, 2-单花生酰甘油, 2-花生四烯酰甘油, （all-Z）-5,8,11,14-二十碳四烯酸-2-羟基-1-（羟甲基）乙酯
经验公式（希尔记法）:
C23H38O4
CAS号:
53847-30-6
分子量:
378.55
MDL编号:
MFCD01862600
UNSPSC代码:
12352200
PubChem化学物质编号:
24891388
NACRES:
NA.77

描述

9:1 mixture of 2-AG and 1-AG

质量水平

100

检测方案

≥98% (HPLC)

形式

solution

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

浓度

~10 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

[H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO

InChI

1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChI key

RCRCTBLIHCHWDZ-DOFZRALJSA-N

基因信息

human ... FAAH(2166)
rat ... Cnr1(25248) , Cnr2(57302)

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生化/生理作用

内源性大麻素受体激动剂。

注意

空气敏感

外形

乙腈溶液

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

闪点(°F)

35.6 °F

闪点(°C)

2 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品

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M Lee et al.
The Journal of pharmacology and experimental therapeutics, 275(2), 529-536 (1995-11-01)
Anandamide (arachidonylethanolamide), isolated from the porcine brain, and 2-arachidonyl-glycerol (2-Ara-Gl), derived from the canine gut, are two recently identified putative endogenous cannabinoid receptor ligands. Both ligands have been reported to possess binding affinity for cannabinoid receptor subtypes, CB1 and CB2.
Ekaterina A Placzek et al.
Neuropharmacology, 55(7), 1095-1104 (2008-09-02)
Anandamide (AEA) and 2-arachidonyl glycerol (2-AG), endogenous ligands for the CB1 and CB2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the actions of delta9-tetrahydrocannabinol (Delta9-THC), a plant-derived cannabinoid. The processes by which AEA and 2-AG are biosynthesized
M Bari et al.
Mini reviews in medicinal chemistry, 6(3), 257-268 (2006-03-07)
Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids, which act as new lipidic mediators. Anandamide (N-arachidonoylethanolamine; AEA) and 2-arachidonoylglycerol (2-AG) are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of (-)-Delta9-tetrahydrocannabinol
Katarzyna Malenczyk et al.
The Journal of biological chemistry, 288(45), 32685-32699 (2013-10-04)
Endocannabinoid signaling has been implicated in modulating insulin release from β cells of the endocrine pancreas. β Cells express CB1 cannabinoid receptors (CB1Rs), and the enzymatic machinery regulating anandamide and 2-arachidonoylglycerol bioavailability. However, the molecular cascade coupling agonist-induced cannabinoid receptor
Jyotpal Singh et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 47(3), 289-300 (2020-02-08)
Cannabidiol (CBD) has been generating increasing interest in medicine due to its therapeutic properties and an apparent lack of negative side effects. Research has suggested that high dosages of CBD can be taken acutely and chronically with little to no
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