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A8185

Sigma-Aldrich

丙氨酸-谷氨酰胺

BioReagent, suitable for cell culture, suitable for insect cell culture

别名:

丙氨酰谷氨酰胺, 丙谷二肽

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About This Item

经验公式（希尔记法）:
C8H15N3O4
CAS号:
39537-23-0
分子量:
217.22
MDL编号:
MFCD00133046
UNSPSC代码:
12352209
PubChem化学物质编号:
24891211
NACRES:
NA.75

产品线

BioReagent

质量水平

300

方案

≥98% (HPLC)

表单

powder

技术

cell culture | insect: suitable
cell culture | mammalian: suitable

颜色

white to off-white

储存温度

room temp

SMILES字符串

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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相关类别

应用

丙氨酰谷氨酰胺可用于：
  • 用作NeuralQ™培养基的补充剂
  • 用作视网膜细胞系生长培养基和培育培养基(IM)的组分
  • 分别应用于视网膜细胞系的实验性治疗

生化/生理作用

丙氨酰谷氨酰胺(Ala-Gln)是一种在哺乳动物细胞培养基中用于替代谷氨酰胺的二肽，因为溶液中谷氨酰胺的不稳定性和分解产物氨的形成可对培养细胞产生有害影响。丙氨酰谷氨酰胺对热力灭菌稳定，比谷氨酰胺具有更低的氨化性，有助于发挥其作为培养基成分的优势。利用丙氨酰谷氨酰胺研究体外多形核白细胞和髓过氧化物酶的活性。

分析说明

该产品经过细胞培养测试（0.5mg/ml）和昆虫细胞培养测试（0.2mg/ml）。它适用于2-10mM的细胞培养和昆虫细胞培养应用。

法律信息

NeuralQ is a trademark of GlobalStem

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储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
0000411567
0000411570
0000411566
0000415318
0000411566

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Vinicius Fernandes Cruzat et al.
Nutrition (Burbank, Los Angeles County, Calif.), 25(4), 428-435 (2008-12-06)
We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations of glutamine, glutamate, and glutathione (GSH) in rats subjected to long-duration
A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics
Alterman JF, et al.
Bio-protocol, 7(16) (2017)
The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium
Christie A, et al.
Biotechnology and Bioengineering, 64(3), 298-309 (1999)
Vinicius Fernandes Cruzat et al.
Cell biochemistry and function, 28(1), 24-30 (2009-11-04)
In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted
Tony E Haynes et al.
Amino acids, 37(1), 131-142 (2009-02-04)
This study tested the hypothesis that L-glutamine (Gln) or L-alanyl-L-glutamine (Ala-Gln) prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Enterocytes of neonatal pigs rapidly hydrolyzed Ala-Gln and utilized Gln. To determine whether Gln or Ala-Gln has a cytoprotective effect, IPEC-1
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