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Merck
CN

A6671

Sigma-Aldrich

放线酰胺素

≥98% (TLC), powder, leucine aminopeptidase inhibitor

别名:

3-[[1-[(2-(羟甲基)-1-吡咯烷基)羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸

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About This Item

经验公式(希尔记法):
C19H35N3O5
CAS号:
分子量:
385.50
Beilstein:
1555250
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

product name

放线酰胺素,

生物来源

synthetic (organic)

质量水平

检测方案

≥98% (TLC)

形式

powder

溶解性

ethanol: 50 mg/mL, clear, colorless

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI key

XJLATMLVMSFZBN-UHFFFAOYSA-N

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一般描述

化学结构:肽

应用

放线酰胺素已被用作抑制C57BL/6小鼠中meprinβ活性的对照。它还已用于通过15N NMR波谱和等温滴定研究EcPDF与放线酰胺素的高亲和力交互效应。

生化/生理作用

放线酰胺素对肽脱甲酰基酶(PDF)具有抑制作用。对革兰氏阳性和苛养型革兰氏阴性微生物有效。
放线酰胺素是亮氨酸氨基肽酶的抑制剂。 放线酰胺素还被用于改善抗菌活性和抗肥胖疗法。

特点和优势

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor
Chen DZ, et al.
Biochemistry, 39(6), 1256-1262 (2000)
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
Jennifer Hamner et al.
Scientific reports, 10(1), 6358-6358 (2020-04-15)
Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury
Diana Mader et al.
Microbes and infection, 12(5), 415-419 (2010-02-17)
The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the
Sonia Fieulaine et al.
PLoS biology, 9(5), e1001066-e1001066 (2011-06-02)
For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups

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