所有图片(5)
别名:
5′-腺苷酸, A-5′-P, AMP
经验公式（希尔记法）:
C10H14N5O7P · xNa+ · yH2O
CAS号:
分子量:
347.22 (anhydrous free acid basis)
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
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生物来源
yeast
质量水平
检测方案
≥99%
形式
powder
溶解性
H2O: soluble
储存温度
−20°C
SMILES字符串
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.
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应用
5′-单磷酸腺苷钠盐已用于：
- 作为再激活培养基组分，再激活从附睾尾提取的小鼠精子，进行精子动力研究
- 作为通过可逆交换实现放大信号(SABRE)方法的底物，建立生物相容性SABRE超极化
- 作为小麦和黑曲霉Aspergillus niger植酸酶检测中的底物
- 用于荧光素酶检测，监测S1S2细胞内的α-突触核蛋白低聚反应
- 研究其对心脏骤停(CA)和复苏大鼠模型中治疗诱导性低温和神经损伤的影响
生化/生理作用
5′-单磷酸腺苷(5′-AMP)可用于增强肉和禽肉汤的鲜味。还可作为食品添加剂满足特别的营养需求。5′-AMP是AMP活化蛋白激酶(AMPK)这类蛋白激酶的激活剂。 AMP可协同肌苷单磷酸(IMP)介导骨骼肌肌动球蛋白分解为肌动蛋白和肌球蛋白。因此，这两种因子可能有参与肌肉解僵。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Yugo Tsuchiya et al.
Bioscience reports, 32(2), 197-213 (2011-08-20)
In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and
Jürgen Knapp et al.
Resuscitation, 85(9), 1291-1297 (2014-07-01)
Animal studies and pathophysiological considerations suggest that therapeutic hypothermia after cardiopulmonary resuscitation is the more effective the earlier it is induced. Therefore this study is sought to examine whether pharmacological facilitated hypothermia by administration of 5'-adenosine monophosphate (AMP) is neuroprotective
D Grahame Hardie
Genes & development, 25(18), 1895-1908 (2011-09-23)
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase
Akihiro Okitani et al.
Bioscience, biotechnology, and biochemistry, 72(8), 2005-2011 (2008-08-08)
We investigated to determine why heating of squid muscle at 60 degrees C induced the liberation of actin from myofibrils. When a mixture of a myofibrillar fraction and a low-molecular sarcoplasmic fraction prepared from squid muscle was heated at 60
Daoying Wang et al.
Journal of the science of food and agriculture, 96(5), 1467-1473 (2015-05-09)
Adenosine 5'-monophosphate (AMP) is often used in meat and poultry soups as a flavor enhancer (flavor modifier), or as food additives for specific nutritional purposes. Our previous research as well as evidence from others showed that actomyosin could be dissociated
实验方案
在测定5′-核苷酸酶活性时，本操作流程使用5′-单磷酸腺苷和一种显色试剂生成的标准曲线而对释放的磷的微摩尔数进行测定。
To measure 5′-nucleotidase activity, this procedure uses adenosine 5’-monophosphate and a color reagent to create a standard curve for determining the micromoles of phosphorus liberated.
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
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