无水柠檬酸粉末

产品名称

无水柠檬酸粉末, anhydrous powder, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

agency

BP
ChP
JP
Ph. Eur.
USP

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE^® EXPERT

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

form

fine powder
solid

feature

RNase and DNase free

expl. lim.

8 %, 65 °F

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

impurities

endotoxins, low

pH

1.7 (20 °C, 100 g/L in H₂O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

bp

200 °C/1013 hPa (decomposition)

mp

153-159 °C (lit.)

solubility

water: 1330 g/L at 20 °C

density

1.665 g/cm³ at 18 °C

cation traces

Al: ≤0.2 ppm
Fe: ≤3 ppm
Pb: ≤2 ppm
heavy metals (as Pb): ≤10 ppm

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

15-25°C

Quality Level

500