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Merck
CN

1.00241

无水柠檬酸粉末

anhydrous powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

别名:

2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid

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关于此项目

线性分子式:
HOC(COOH)(CH2COOH)2
化学文摘社编号:
77-92-9
分子量:
192.12
UNSPSC Code:
12352106
EC Index Number:
201-069-1
E Number:
E330
MDL number:
MFCD00011669
Beilstein/REAXYS Number:
782061

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产品名称

无水柠檬酸粉末, anhydrous powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

agency

BP
JP
Ph. Eur.
USP

reg. compliance

FCC

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

form

fine powder

potency

3000 mg/kg LD50, oral (Rat)

expl. lim.

8 %, 65 °F

pH

1.7 (20 °C, 100 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

bp

200 °C/1013 hPa (decomposition)

mp

153-159 °C (lit.)

solubility

1330 g/L

density

1.665 g/cm3 at 18 °C

cation traces

Al: ≤0.2 ppm
As: ≤1 ppm
Hg: ≤1 ppm
Pb: ≤0.5 ppm
heavy metals (as Pb): ≤5 ppm

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

Quality Level

500

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相关类别

Application

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove® Essential is citric acid present in its water-free, powder form.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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