639869
4-苯基哌啶
97%
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经验公式（希尔记法）:
C11H15N
化学文摘社编号:
分子量:
161.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
212-243-1
Beilstein/REAXYS Number:
124508
MDL number:
产品名称
4-苯基哌啶, 97%
InChI key
UTBULQCHEUWJNV-UHFFFAOYSA-N
InChI
1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
SMILES string
C1CC(CCN1)c2ccccc2
assay
97%
mp
61-65 °C (lit.)
functional group
phenyl
Quality Level
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
R A Glennon et al.
Journal of medicinal chemistry, 34(12), 3360-3365 (1991-12-01)
sigma receptors may represent an exciting new approach for the development of novel psychotherapeutic agents. Unfortunately, many of the commonly used sigma ligands lack selectivity (e.g., many bind at phencyclidine or dopamine receptors) or suffer from other serious drawbacks. Recently
A G Ishkov et al.
Voprosy meditsinskoi khimii, 38(2), 25-28 (1992-03-01)
A rate of utilization of 4-phenyl piperidine and its 12 derivatives by brain monoamine oxidase (MAO) was studied as compared with typical neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The enzyme was isolated from P2 synaptosomal fraction of brain corpus striatum of Sprague-Dawley rats.
M G Russell et al.
Journal of medicinal chemistry, 35(11), 2025-2033 (1992-05-29)
This paper describes the synthesis of some conformationally restricted 4-phenylpiperidine analogues and their affinities for the guinea pig cerebellum sigma recognition site ([3H]-DTG) and the rat striatum dopamine D2 receptor ([3H]-(-)-sulpiride) in order to develop potent selective sigma ligands as
Clandestine drug synthesis.
W H Soine
Medicinal research reviews, 6(1), 41-74 (1986-01-01)
Diane K Luci et al.
Bioorganic & medicinal chemistry letters, 17(23), 6489-6492 (2007-10-16)
Various 4-phenylpiperidine-benzoxazin-3-ones were synthesized and biologically evaluated as urotensin-II (U-II) receptor antagonists. Compound 12i was identified from in vitro evaluation as a low nanomolar antagonist against both rat and human U-II receptors. This compound showed in vivo efficacy in reversing
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