PTPN1
protein tyrosine phosphatase, non-receptor type 1
别名:
PTP1B
物种:
Human PTPN1 (5770), Mouse Ptpn1 (19246), Rat Ptpn1 (24697), chicken PTPN1 (395688), Zebrafish ptpn1 (30081), cow PTPN1 (508658), Domestic Rabbit PTPN1 (100354834), Horse PTPN1 (100052066), domestic cat PTPN1 (101099626), dog PTPN1 (477263) ...展开
UniProtKB ID:
基因ID:
- Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
- Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
- Rat(24697) protein tyrosine phosphatase, non-receptor type 1
- chicken(395688) protein tyrosine phosphatase, non-receptor type 1
- Zebrafish(30081) protein tyrosine phosphatase, non-receptor type 1
- cow(508658) protein tyrosine phosphatase, non-receptor type 1
- Domestic Rabbit(100354834) protein tyrosine phosphatase, non-receptor type 1
- Horse(100052066) protein tyrosine phosphatase, non-receptor type 1
- domestic cat(101099626) protein tyrosine phosphatase, non-receptor type 1
- dog(477263) protein tyrosine phosphatase, non-receptor type 1
- naked mole-rat(101696680) protein tyrosine phosphatase, non-receptor type 1
- domestic guinea pig(100730699) protein tyrosine phosphatase, non-receptor type 1
- sheep(101118209) protein tyrosine phosphatase, non-receptor type 1
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ELISA
货号
说明
物种
Antibodies
货号
说明
物种反应性
应用
Anti-PTP1B Antibody (Oxidized), clone scFvs 45, clone scFvs 45, from chicken,
物种反应性
human
应用
immunoprecipitation (IP)
Anti-PTPN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTP1B Antibody, clone FG6-1G, clone FG6-1G, from mouse,
物种反应性
human
应用
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-PTP1B (pSer50) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, monkey, mouse, rat
应用
western blot
Anti-PTPN1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rat
应用
western blot
Small Molecule - Inhibitor
Kits
货号
说明
物种
PTP Assay Kit 1, PTP Assay Kit 1 can be used to detect PTP-1B activity by dephosphorylation of the phosphopeptide (RRLIEDAEpYAARG) using malachite green detection, or by hydrolysis of pNPP.,
物种
human
Proteins
货号
说明
物种
PTP1B (1-321)/PTPN1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
物种
human
PTP1B (1-321)/PTPN1 Active from mouse, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
物种
human
PTPN1, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human