Traditional Strong and Hindered Bases

Phosphazene Bases | Verkade's Superbases | Preservation of Reagents | Schlenk Type Glassware

We offer specialized bases, such as the phosphazene or Verkade's bases, as well as traditional bases, such as DBU, DBN, n-BuLi etc (Tables 2, 3 and 4). These traditional strong and/or hindered bases are well known and frequently used tools in organic synthesis. For example, Proton Sponge^® reagent (Product No. 14795) is an extremely strong base for a tertiary amine. Protonation releases the strain of the two amines, resulting in a so-called "proton sponge". Table 1 lists the basicity strength for some of our traditional bases.

*Absolute values in acetonitrile. Data obtained from Prof. Dr. Schwesinger, University of Freiburg, Germany

The general strength of the traditional lithium bases follows the order:
LDA < MeLi < n-BuLi < sec-BuLi < tert-BuLi