- Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
Cell stem cell (2017-12-05)
Xiaowei Chen, Huan Deng, Michael J Churchill, Larry L Luchsinger, Xing Du, Timothy H Chu, Richard A Friedman, Moritz Middelhoff, Hongxu Ding, Yagnesh H Tailor, Alexander L E Wang, Haibo Liu, Zhengchuan Niu, Hongshan Wang, Zhengyu Jiang, Simon Renders, Siu-Hong Ho, Spandan V Shah, Pavel Tishchenko, Wenju Chang, Theresa C Swayne, Laura Munteanu, Andrea Califano, Ryota Takahashi, Karan K Nagar, Bernhard W Renz, Daniel L Worthley, C Benedikt Westphalen, Yoku Hayakawa, Samuel Asfaha, Florence Borot, Chyuan-Sheng Lin, Hans-Willem Snoeck, Siddhartha Mukherjee, Timothy C Wang
PMID29198940
ABSTRACT
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc