- WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A
WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A
American journal of physiology. Heart and circulatory physiology (2017-04-16)
Shakun Karki, Doan T M Ngo, Melissa G Farb, Song Young Park, Samantha M Saggese, Naomi M Hamburg, Brian Carmine, Donald T Hess, Kenneth Walsh, Noyan Gokce
PMID28411232
ABSTRACT
Experimental studies have suggested that Wingless-related integration site 5A (WNT5A) is a proinflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat depots has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation, and metabolic dysfunction. We have recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of antiangiogenic factor VEGF-A
MATERIALS