- Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Organic & biomolecular chemistry (2012-11-08)
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
PMID23132282
ABSTRACT
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
MATERIALS
Product Number
Brand
Product Description
Sorbitol, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Sorbitol F solution, 70 wt. % in H2O, Contains mainly D-sorbitol with lesser amounts of other hydrogenated oligosaccharides
Sigma-Aldrich
D-Sorbitol, ≥98% (GC), BioReagent, suitable for cell culture, suitable for plant cell culture