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CN
  • 2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine.

2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine.

Bioorganic & medicinal chemistry letters (2001-12-12)
Akimitsu Okamoto, Kazuo Tanaka, Isao Saito
PMID11738582
ABSTRACT

2-Amino-7-deazaadenine ((AD)A) was incorporated into oligodeoxynucleotides (ODN) and their base-pairing properties with natural nucleobases were investigated. In melting temperature (T(m)) experiments, the duplex containing an (AD)A/C base pair showed a high stability comparable to that containing (AD)A/T base pair. Destabilization of the duplex usually observed for existing degenerate bases was not observed. However, the incorporation efficiency of dCTP was only 1.8% for TTP in single-nucleotide insertion reactions using polymerase.

MATERIALS
Product Number
Brand
Product Description
722332
Sigma-Aldrich
6-Amino-7-deazapurine, 97%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
1 g
Please contact Customer Service for Availability
CN¥1,070.90