- Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979.
Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979.
The Journal of general and applied microbiology (2020-07-17)
Amila Pramisandi, Kazuyuki Dobashi, Mihoko Mori, Kenichi Nonaka, Atsuko Matsumoto, Toshiyuki Tokiwa, Mayuka Higo, Kristiningrum, Eri Amalia, Arif Nurkanto, Daniel Ken Inaoka, Danang Waluyo, Kiyoshi Kita, Tomoyoshi Nozaki, Satoshi Ōmura, Kazuro Shiomi
PMID32669511
ABSTRACT
An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin (1), which inhibits PfDHODH, with an IC50 value of 5.9 μM, along with other metabolites: mitorubrinol (2) and mitorubrinic acid (3). Compounds 1 and 2 inhibited PfDHODH but displayed no activity against the human orthologue. They also inhibited P. falciparum 3D7 cell growth in vitro. Compound 3 showed little PfDHODH inhibitory activity or cell growth inhibitory activity.
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