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Merck
CN

V900477

HEPES

99.5%, crystalline powder, reagent grade, Vetec™

Synonym(s):

4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)

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About This Item

Empirical Formula (Hill Notation):
C8H18N2O4S
CAS Number:
7365-45-9
Molecular Weight:
238.30
Beilstein:
883043
EC Number:
230-907-9
MDL number:
MFCD00006158
UNSPSC Code:
12161700
PubChem Substance ID:
329829878

Key Documents

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Product Name

HEPES, Vetec™, reagent grade, 99.5%

grade

reagent grade

product line

Vetec™

Assay

99.5%

form

crystalline powder

pH

5.0-6.5 (25 °C, 238 g/L)

useful pH range

6.8-8.2

pKa (25 °C)

7.5

solubility

water: 500 mg/mL, clear, colorless

SMILES string

OCCN1CCN(CC1)CCS(O)(=O)=O

InChI

1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

InChI key

JKMHFZQWWAIEOD-UHFFFAOYSA-N

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General description

HEPES, a zwitterionic buffer having a pH range of 6.8-8.2, is one among the 20 Good′s buffers. It′s commonly used in cell culture applications as it helps in maintaining the physiological pH.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7805V
WXBF7048V
WXBF6449V
WXBF5193V
WXBF5195V

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Acid-base buffering in organ preservation solutions as a function of temperature: new parameters for comparing buffer capacity and efficiency
Baicu SC and Taylor MJ
Cryobiology, 45(1), 33-48 (2002)
Evidence-based guidelines for controlling pH in mammalian live-cell culture systems
Michl J, et al.
Communications biology, 2(1), 1-12 (2019)
Bérangère Pinan-Lucarré et al.
Nature, 511(7510), 466-470 (2014-06-05)
Because most neurons receive thousands of synaptic inputs, the neuronal membrane is a mosaic of specialized microdomains where neurotransmitter receptors cluster in register with the corresponding presynaptic neurotransmitter release sites. In many cases the coordinated differentiation of presynaptic and postsynaptic
P Dey et al.
Oncogene, 33(33), 4213-4225 (2013-10-01)
Estrogen receptor β (ERβ) is emerging as a critical factor in understanding prostate cancer biology. Although reduced in prostate cancer above Gleason grade 3, ERβ is a potential drug target at the initial stage of the disease. In human prostate
Frédéric Perros et al.
Journal of the American College of Cardiology, 65(7), 668-680 (2015-02-14)
Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting vasoconstriction, smooth muscle proliferation, and inflammation. This study sought to test the hypothesis that nebivolol, a β1-antagonist and β2,3-agonist, may improve PAH and
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