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V900429

Sigma-Aldrich

N-Acetyl-L-cysteine

98%, Vetec™

Synonym(s):

LNAC, NAC

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250 ML
CN¥1,869.36

CN¥1,869.36

Available to ship onApril 16, 2025Details

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250 ML
CN¥1,869.36

About This Item

Linear Formula:
HSCH2CH(NHCOCH3)CO2H
CAS Number:
616-91-1
Molecular Weight:
163.19
Beilstein:
1724426
EC Number:
210-498-3
MDL number:
MFCD00004880
UNSPSC Code:
12352209
PubChem Substance ID:
329829836

CN¥1,869.36

Available to ship onApril 16, 2025Details

Request a Bulk Order

Product Name

N-Acetyl-L-cysteine, Vetec™, reagent grade, 98%

grade

reagent grade

product line

Vetec™

Assay

98%

form

powder

color

white to off-white

mp

106-108 °C (lit.)

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

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application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

application(s)

food and beverages

application(s)

environmental
food and beverages

material

UHMW PE frit, polypropylene tube

material

UHMW PE frit, polypropylene tube

material

PTFE frit, polypropylene tube

material

polypropylene tube

agency

suitable for DIN 38407-42

agency

suitable for DIN 38407-42, suitable for EPA 1633, suitable for EPA 533, suitable for EPA 537.1, suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b, suitable for EPA OTM-45, suitable for GB 31604.35-2016, suitable for ISO 21675 2019, suitable for ISO 25101, suitable for ISO/CEN 15968-2010

agency

-

agency

-

reg. compliance

suitable for FDA C-010.02

reg. compliance

suitable for FDA C-010.02

reg. compliance

-

reg. compliance

-

product line

Visiprep™

product line

Visiprep™

product line

Visiprep™

product line

-

Application


  • Antioxidant Assay Development: N-Acetyl-L-cysteine (NAC) is used in the metabolic activation and assessment of cytotoxicity of gramine mediated by CYP3A, showcasing its importance in biochemical assays that measure oxidative stress, a critical factor in IVD reagent development (Gao et al., 2024).

  • Cell Differentiation and NF-κB Inhibition: NAC′s role extends to inducing oxidative stress and inhibiting NF-κB pathways, which is crucial for the differentiation of cells in AML treatment. This application demonstrates NAC′s utility in clinical diagnostic reagents aimed at cancer treatment and research (Silva et al., 2024).

  • Liver Injury Alleviation: Highlighting its therapeutic applications, NAC is used in alleviating acetaminophen overdose-induced liver injury, underlining its potential use in clinical settings and importance in developing therapeutic IVD assays (Chen et al., 2024).

  • Enhanced Cancer Treatment Efficacy: Employed in combination therapies, NAC is used to treat posterior gastric pseudomyxoma peritonei, offering insights into its role as a biochemical agent that enhances the efficacy of cancer treatments in diagnostic and therapeutic applications (Sun et al., 2024).

  • Regulation of Cell Cycle and Autophagy: NAC′s interactions with 1-Methoxyisobrassinin in ovarian cancer cells illustrate its capability to modulate cell cycle regulation, apoptosis, and autophagy, underpinning its significant role in the development of biomarker detection assays and other IVD products (Zigová et al., 2024).

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    WXBF4384V
    WXBF1763V
    WXBD8971V
    WXBD6655V
    WXBD4000V

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    Suzanne M Cloonan et al.
    Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
    Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
    Michael Berk et al.
    Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
    N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of
    Yuval Samuni et al.
    Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
    N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
    Luigi Franchi et al.
    Journal of immunology (Baltimore, Md. : 1950), 193(8), 4214-4222 (2014-09-17)
    The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1β and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.
    Taeshin Kim et al.
    Endocrinology, 156(6), 2185-2199 (2015-04-08)
    The appropriate control of synthesis and secretion of the gonadotropin hormones LH and FSH by pituitary gonadotropes is essential for the regulation of reproduction. The hypothalamic neuropeptide GnRH is the central regulator of both processes, coordinating secretion with transcription and
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