V900421
Uridine
Vetec™, reagent grade, 99%
Synonym(s):
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
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About This Item
Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
Molecular Weight:
244.20
PubChem Substance ID:
UNSPSC Code:
12352204
Beilstein/REAXYS Number:
754902
MDL number:
Assay:
99%
Form:
powder
Solubility:
water: 0.1 M, clear, colorless
Product Name
Uridine, Vetec™, reagent grade, 99%
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-XVFCMESISA-N
grade
reagent grade
product line
Vetec™
assay
99%
form
powder
mp
163-167 °C (lit.)
solubility
water: 0.1 M, clear, colorless
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Biochem/physiol Actions
Uridine is an essential compound involved in maintaining cellular function and energy metabolism. It aids in multiple biological processes, including RNA synthesis, the synthesis of biomembranes, and glycosylation. Furthermore, uridine serves as a precursor molecule for UDP-glucose, a vital component in the synthesis and storage of glycogen in the liver. In addition, studies have shown that uridine reduces cytotoxicity and improves neurophysiological functions. It is involved in regulating various normal physiological processes in the body, including the cardio-circulatory, reproductive, peripheral and central nervous, and respiratory systems.
General description
Uridine is a pyrimidine nucleoside composed of uracil and ribose that is readily taken up by the brain. This compound is synthesized de novo in mammals. It is found circulating in the blood and cerebrospinal fluid.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
Laure Jobert et al.
Molecular cell, 49(2), 339-345 (2012-12-19)
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that removes uracil and oxidised pyrimidines from DNA. We show that SMUG1 interacts with the pseudouridine synthase Dyskerin (DKC1) and colocalizes with DKC1 in nucleoli and Cajal bodies.
Juma A M Ali et al.
Molecular pharmacology, 83(2), 439-453 (2012-11-29)
African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis
Yuan Zhou et al.
Nucleic acids research, 41(13), 6664-6673 (2013-05-10)
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs)
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