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Key Documents

1724500

USP

Zidovudine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

3′-Azido-3′-deoxythymidine, AZT, Azidothymidine, ZDV, Zidovudine

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About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
Molecular Weight:
267.24
Beilstein:
3595791
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

zidovudine

manufacturer/tradename

USP

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

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Show Differences

1 of 4

This Item
ZIQ7015T0CZIX7015P0CZIQ7005T0C
output

product water quality: type 1 water (18.2 MΩ·cm)

output

product water quality: type 1 water (18.2 MΩ·cm)
product water quality: type 2 water (> 5 MΩ·cm)

output

product water quality: type 2 water (> 5 MΩ·cm)

output

product water quality: type 2 water (> 5 MΩ·cm)
product water quality: type 1 water (18.2 MΩ·cm)

parameter

1.5 L/min flow rate, 9.1 kg operating weight (19.84 lb)

parameter

≤2 L/min distribution flow rate (Type I), 15 L/hr flow rate (Type II), 30 kg operating weight (66 lb), 300 L/day max. usage

parameter

15 L/hr flow rate, 30.0 kg operating weight (66 lb), 300 L/day max. usage, ~2 L/min distribution flow rate

parameter

≤2 L/min distribution flow rate (Type I), 100 L/day max. usage, 26.0 kg operating weight (57.3 lb), 5 L/hr flow rate (Type II)

input

feed water nature ultrapure water

input

feed water nature potable tap water

input

feed water nature potable tap water

input

feed water nature potable tap water

packaging

pkg of 1 unit

packaging

pkg of 1 unit

packaging

pkg of 1 unit (System + E-POD®)

packaging

pkg of 1 unit

conductivity

0.055 μS/cm (Ultrapure water)

conductivity

0.055 μS/cm at 25 °C (Ultrapure Water), <0.2 μS/cm at 25 °C (Pure Water)

conductivity

0.2 μS/cm at 25 °C (water output)

conductivity

0.055 μS/cm at 25 °C (Ultrapure Water), <0.2 μS/cm at 25 °C (Pure Water)

AC/DC input

100 V / 240 V, 50-60 Hz

AC/DC input

100 V / 230 V AC, 50-60 Hz

AC/DC input

100 V / 240 V, 50-60 Hz

AC/DC input

100 V / 230 V AC, 50-60 Hz

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Zidovudine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Abacavir, Lamivudine and Zidovudine Tablets
  • Lamivudine and Zidovudine Tablets
  • Zidovudine
  • Zidovudine Capsules
  • Zidovudine Injection
  • Zidovudine Oral Solution
  • Zidovudine Tablets

Biochem/physiol Actions

Reverse transcriptase inhibitor active against HIV-1 virus.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Certificates of Analysis (COA)

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Y-H Lai et al.
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Replicating virus vectors are attractive tools for anticancer gene therapy, but the potential for adverse events due to uncontrolled spread of the vectors has been a major concern. To design a tumor-specific retroviral replicating vector (RRV), we replaced the U3
Youko Suehiro et al.
British journal of haematology, 169(3), 356-367 (2015-01-24)
Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type-I (HTLV-I)-infected T cell malignancy with poor prognosis. We herein developed a novel therapeutic vaccine designed to augment an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL) response that has
H Stedt et al.
Cancer gene therapy, 22(3), 130-137 (2015-01-24)
Malignant gliomas (MGs) are the most common malignant primary brain tumors with a short life estimate accompanied by a marked reduction in the quality of life. Herpes Simplex virus-1 thymidine kinase ganciclovir (HSV-TK/GCV) system is the best characterized enzyme prodrug
Roger Badia et al.
Antimicrobial agents and chemotherapy, 58(8), 4318-4327 (2014-05-14)
Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor
Richard M Hoglund et al.
British journal of clinical pharmacology, 79(4), 636-649 (2014-10-10)
Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and their respective metabolites desbutyl-lumefantrine and dihydroartemisinin, and the HIV

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