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Merck
CN

1643260

USP

Tamsulosin hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H28N2O5S · HCl
CAS Number:
106463-17-6
Molecular Weight:
444.97
NACRES:
NA.24
PubChem Substance ID:
329751218
UNSPSC Code:
41116107
MDL number:
MFCD00922997

Key Documents

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Product Name

Tamsulosin hydrochloride, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

SMILES string

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

grade

pharmaceutical primary standard

API family

tamsulosin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Tamsulosin hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Tamsulosin Hydrochloride Capsules
  • Dutasteride and Tamsulosin Hydrochloride Capsules

Biochem/physiol Actions

Tamsulosin is a α1A/1D-adrenoceptor antagonist; Used as a treatment of BPH (benign prostatic hypertrophy).
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Dutasteride and Tamsulosin Hydrochloride Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(5) (2023)
Tamsulosin Hydrochloride
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 4211-4211 (2020)
Tamsulosin Hydrochloride Capsules
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(3) (2022)
Shuo Yang et al.
The AAPS journal, 16(4), 860-871 (2014-05-31)
Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron
Nannan Chu et al.
Clinical therapeutics, 37(2), 462-472 (2014-12-04)
The primary aim of this study was to evaluate whether there was clinically significant pharmacokinetic (PK) interaction between finasteride and tamsulosin in healthy Chinese male subjects. This was an open-label, randomized, 3-period, crossover study. Subjects received single and multiple doses
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