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USP

Sertraline hydrochloride racemic mixture

Name: Sertraline hydrochloride racemic mixture
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(±)-Sertraline hydrochloride, 1R,4R)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇Cl₂N · HCl

CAS Number:

79617-89-3

Molecular Weight:

342.69

MDL number:

MFCD00895772

UNSPSC Code:

41116107

PubChem Substance ID:

329751091

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

sertraline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

Gene Information

human ... SLC6A4(6532)

Related Categories

Analytical Reference Standards

General description

Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

Application

Sertraline hydrochloride racemic mixture USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Sertraline Hydrochloride Tablets
Sertraline Hydrochloride

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302,H373,H410

Precautionary Statements

P260 - P264 - P273 - P301 + P312 - P314 - P391

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of sertraline hydrochloride on dialysis hypotension.

Dheenan S

American Journal of Kidney Diseases, 31(4), 624-630 (1998)

Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test species.

Minagh E

Ecotox. Environ. Safety, 72(2), 434-440 (2009)

Cannabinoids prevent the effects of a footshock followed by situational reminders on emotional processing.

Nachshon Korem et al.

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Posttraumatic stress disorder (PTSD) can develop following exposure to a traumatic event. Hence, what we do in the first few hours after trauma exposure may alter the trajectory of PTSD. We examined whether cannabinoids can prevent the effects of a

Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats.

Baolian Wang et al.

Journal of ethnopharmacology, 155(3), 1473-1482 (2014-08-06)

Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic effect. To

Development and validation of LC-MSMS assay for the determination of the prodrug dabigatran etexilate and its active metabolites in human plasma.

Eman G Nouman et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 37-45 (2015-03-24)

Dabigatran etexilate (DABE) is a low-molecular-weight prodrug that is converted after oral administration to dabigatran (DAB)-a directly acting oral anticoagulant. In this study, an LC-MSMS assay was developed and validated for the determination of DABE, free DAB and its equipotent

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