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1604803

USP

Ritonavir

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

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About This Item

Empirical Formula (Hill Notation):
C37H48N6O5S2
CAS Number:
155213-67-5
Molecular Weight:
720.94
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

ritonavir

form

powder

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to tan

solubility

acetonitrile: slightly soluble
ethanol: freely soluble
methanol: freely soluble
methylene chloride: freely soluble
water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Ritonavir belongs to the group of protease inhibitors that are widely used in combination with other drugs in the prevention of HIV. Its mode of action involves binding to the active site of the protease enzyme and preventing the further maturation of new viral particles.

Application

Ritonavir USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Ritonavir Capsules
  • Ritonavir Tablets
  • Ritonavir Oral Solution
  • Lopinavir and Ritonavir Tablets
  • Lopinavir and Ritonavir Oral Solution

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Precautionary Statements

P261 - P280 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lopinavir and Ritonavir Oral Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(4), 2666-2666 (2015)
Ritonavir Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(4), 3920-3920 (2013)
Ritonavir
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(4), 3912-3912 (2020)
Lopinavir and Ritonavir Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(4), 2670-2670 (2013)
Ritonavir USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(4), 3880-3880 (2020)
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