Skip to Content
Merck
CN
All Photos(1)

Documents

1444279

USP

Mirtazapine

United States Pharmacopeia (USP) Reference Standard

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Empirical Formula (Hill Notation):
C17H19N3
CAS Number:
85650-52-8
Molecular Weight:
265.35
MDL number:
MFCD00865427
UNSPSC Code:
41116107
PubChem Substance ID:
329750473
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

mirtazapine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

InChI key

RONZAEMNMFQXRA-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HTR2A(3356) , HTR2C(3358)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mirtazapine USP reference standard for use in specified quality tests and assays. 

Also used to prepare standard, standard stock, and system suitability solution for the assay and identification by using liquid chromatography coupled with UV detector according to the given below monographs of United States Pharmacopeia (USP): 
  • Mirtazapine Orally Disintegrating Tablets
  • Mirtazapine Compounded Oral Suspension, Veterinary
  • Mirtazapine

Biochem/physiol Actions

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H336

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mirtazapine Orally Disintegrating Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(2), 2980-2980 (2020)
Mirtazapine Compounded Oral Suspension, Veterinary
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(5), 2977-2977 (2019)
Mirtazapine
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(6), 2976-2976 (2021)
Michael Paulzen et al.
Psychopharmacology, 232(4), 807-813 (2014-08-26)
The aim of this study was to investigate the distribution pattern of mirtazapine and its metabolite normirtazapine (N-desmethylmirtazapine) in blood and cerebrospinal fluid (CSF). Concentrations of mirtazapine were measured in blood serum and CSF of 16 patients treated with daily
Hun Soo Chang et al.
Journal of clinical psychopharmacology, 34(4), 446-454 (2014-06-10)
We tested for the association of HTR1A and 5-HTT genetic polymorphisms with treatment response to mirtazapine and evaluated the interactive effect between the polymorphisms in 283 patients with major depressive disorder. Korean subjects with diagnosis of major depressive disorder using
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service