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1426002

USP

Methyldopa

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Methyl-DOPA sesquihydrate, 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, MK-351, Methyl-L-DOPA
Empirical Formula (Hill Notation):
C10H13NO4 · 1.5H2O
CAS Number:
41372-08-1
Molecular Weight:
238.24
Beilstein:
2417244
MDL number:
MFCD00004186
UNSPSC Code:
41116107
PubChem Substance ID:
329750434
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

methyldopa

manufacturer/tradename

USP

mp

≥300 °C

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1

InChI key

CJCSPKMFHVPWAR-JTQLQIEISA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Application

Methyldopa USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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A new method for the determination of tranexamic acid (TA) in human plasma using high performance liquid chromatography with tandem mass spectrometric detection was described. TA and the internal standard, methyldopa, was extracted from a 200 l plasma sample by
P A van Zwieten et al.
Hypertension (Dallas, Tex. : 1979), 6(5 Pt 2), II28-II33 (1984-09-01)
Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of
Li-Ting Liao et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)
Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of

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