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Menthol

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
(−)-Menthol, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol, 5-Methyl-2-(1-methylethyl)cyclohexanol
Empirical Formula (Hill Notation):
C10H20O
CAS Number:
2216-51-5
Molecular Weight:
156.27
Beilstein:
1902293
MDL number:
MFCD00062979
UNSPSC Code:
41116107
PubChem Substance ID:
329750355
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

menthol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O

InChI

1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1

InChI key

NOOLISFMXDJSKH-KXUCPTDWSA-N

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General description

Menthol is an alcohol extracted from various mint oils or prepared synthetically. It exists in two forms: levorotatory (l-menthol), which can be found in natural or synthetic sources, and racemic (dl-menthol).

Application

Menthol USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard, and standard stock solution during the assay, and impurity analysis by using gas chromatography in conjunction with flame ionization detector according to the given below monographs of United States Pharmacopeia (USP): 
  • Menthol Lozenges
  • Menthol
  • Tetracaine and Menthol Ointment
  • Benzocaine and Menthol Topical Aerosol

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Menthol
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 49(5) (2022)
Titeyut Wongsanao et al.
Pharmaceutical biology, 59(1), 854-859 (2021-07-02)
Psidium guajava L. (Myrtaceae) leaf contains a wide variety of bioactive compounds that contribute valuable effects on human well-being. This study investigates the influence of guava leaf extract-menthol toner on thermoregulation, including perspiration, skin temperature, and recovery heart rate. This
Tetracaine and Menthol Ointment?
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 4294-4294 (2013)
Benzocaine and Menthol Topical Aerosol
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(1), 518-518 (2016)
Menthol Lozenges
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(2), 2782-2782 (2013)
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