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Merck
CN

1269152

USP

Famciclovir

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester, BRL 42810

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About This Item

Empirical Formula (Hill Notation):
C14H19N5O4
CAS Number:
104227-87-4
Molecular Weight:
321.33
NACRES:
NA.24
PubChem Substance ID:
329749829
UNSPSC Code:
41116107
MDL number:
MFCD00866964

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Product Name

Famciclovir, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)

SMILES string

CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O

InChI key

GGXKWVWZWMLJEH-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

famciclovir

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Famciclovir USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Famciclovir Tablets
  • Famciclovir Compounded Oral Suspension

Biochem/physiol Actions

Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Famciclovir Tablets USP Monograph Method Using a Purospher™ STAR RP-8 endcapped HPLC Column and UV Detection

Following the new USP monograph for Famciclovir Tablets, Purospher™ STAR RP-8 endcapped HPLC columns can be used to monitor organic impurities in Famciclovir tablet formulations. Famciclovir is an antiviral drug indicated for the treatment of herpes zoster, herpes simplex virus 2 (genital herpes), herpes labialis (cold sores), etc.

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