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1254508

USP

Estriol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene

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About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
50-27-1
Molecular Weight:
288.38
Beilstein:
2508172
MDL number:
MFCD00003691
UNSPSC Code:
41116107
PubChem Substance ID:
329749756
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

estriol

manufacturer/tradename

USP

mp

280-282 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O

InChI

1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

InChI key

PROQIPRRNZUXQM-ZXXIGWHRSA-N

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General description

Estriol is found to be a major estrogen in pregnant women. It originates in the placenta from the estrogen precursors, made by the fetal adrenal gland and liver. Estriol levels are directly related to the delivery of the fetus and serve as an index of the fetal well-being.

Application

Estriol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Estriol Compounded Vaginal Cream

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360FD,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of 17 $\beta$-estradiol in pharmaceutical preparation by UV spectrophotometry and high performance liquid chromatography methods
Yilmaz B and Kadioglu Y
Arabian Journal of Chemistry, 10(3), S1422-S1428 (2017)
Development and validation of a liquid chromatographic method for the simultaneous determination of estradiol, estriol, estrone, and progesterone in pharmaceutical preparations
Wilson P
Journal of AOAC (Association of Official Analytical Chemists) International, 92(3), 846-854 (2009)
"Handbook of Poylmer-Liquid Interaction Parameters and Solubility Parameters ", 27(22), 4431-4438 (2012)
Simultaneous determination of natural and synthetic estrogens by EKC using a novel microemulsion
Tripodi V, et al.
Electrophoresis, 27(22), 4431-4438 (2006)

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