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1226003

USP

Doxycycline hyclate

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Doxycycline hydrochloride hemiethanolate hemihydrate
Empirical Formula (Hill Notation):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
CAS Number:
Molecular Weight:
512.94
Beilstein:
5702728
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

doxycycline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

InChI key

HALQELOKLVRWRI-ZVACAFRPSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxycycline hyclate USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard, system suitability stock, and sensitivity solution for the assay, impurity analysis, and performance test by using liquid chromatography in conjunction with UV detector according to the given below monographs of United States Pharmacopeia (USP): 
  • Doxycycline Hyclate
  • Doxycycline Hyclate Delayed-Release Tablet  
  • Doxycycline Tablets  
  • Doxycycline Capsules  
  • Doxycycline Hyclate Tablets

Biochem/physiol Actions

Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.

Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Doxycycline Capsules
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 1519-1519 (2022)
Doxycycline Hyclate Delayed-Release Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(6), 1539-1539 (2022)
Doxycycline Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 1527-1527 (2022)
Doxycycline Hyclate
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(3) (2022)
Doxycycline Hyclate Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(2), 1537-1537 (2022)

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