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USP

Diethylene glycol

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol
Linear Formula:
(HOCH2CH2)2O
CAS Number:
Molecular Weight:
106.12
Beilstein:
969209
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

API family

diethylene glycol

autoignition temp.

442 °F

expl. lim.

2-12.3 %

manufacturer/tradename

USP

density

1.118 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diethylene glycol USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard, system suitability, and standard stock solution for impurity analysis and identification according to the given below monographs of United States Pharmacopeia (USP):
  • Propylene Glycol
  • Glycerin
  • Polyethylene Glycol 3350

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glycerin
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 28(4), 2123-2123 (2020)
Propylene Glycol
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 33(2), 3753-3753 (2020)
Polyethylene Glycol 3350
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(4), 3584-3584 (2020)
Nestor R Sosa et al.
Annals of emergency medicine, 64(1), 38-47 (2014-01-21)
Diethylene glycol is a toxic industrial solvent responsible for more than 13 mass poisonings since 1937. Little is known about the clinical spectrum, progression, and neurotoxic potential of diethylene glycol-associated disease because of its high mortality and the absence of
Leo J Schep et al.
Clinical toxicology (Philadelphia, Pa.), 47(6), 525-535 (2009-07-10)
Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings

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