1123000
USP
Chlorpheniramine maleate
United States Pharmacopeia (USP) Reference Standard
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Synonym(s):
(±)-Chlorpheniramine maleate salt
Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
Molecular Weight:
390.86
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
pharmaceutical primary standard
API family
chlorpheniramine
manufacturer/tradename
USP
mp
130-135 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information
human ... HRH1(3269)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Chlorpheniramine maleate USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Chlorpheniramine Maleate Tablets
- Chlorpheniramine Maleate Oral Solution
- Chlorpheniramine Maleate Extended-Release Capsules
- Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Oral Solution
- Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide Tablets
- Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Extended-Release Capsules
- Penicillin G Procaine, Dihydrostreptomycin Sulfate, Chlorpheniramine Maleate, and Dexamethasone Injectable Suspension
Biochem/physiol Actions
H1 Histamine receptor antagonist.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Juan José Saez et al.
Cells, 10(2) (2021-02-13)
LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments. Upon T cell activation the intracellular pool of LAT
L Canto-de-Souza et al.
Neuroscience letters, 587, 11-16 (2014-12-20)
Several findings have pointed to the role of histaminergic neurotransmission in the modulation of anxiety-like behaviors and emotional memory. The elevated plus-maze (EPM) test has been widely used to investigate the process of anxiety and also has been used to
Hao Lou et al.
Drug development and industrial pharmacy, 40(7), 910-918 (2013-04-30)
To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles into orally disintegrating films (ODF) and orally disintegrating tablets (ODT) for pediatric uses. Spray drying of water-in-oil emulsion was utilized to
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Cheryl C Y Loh et al.
PloS one, 9(10), e110800-e110800 (2014-10-25)
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on
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