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1118350

USP

Chloroquine Related Compound D

Name: Chloroquine Related Compound D
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, Monodesethylchloroquine

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₂ClN₃

CAS Number:

1476-52-4

Molecular Weight:

291.82

MDL number:

MFCD00871808

UNSPSC Code:

41116107

NACRES:

NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

USP

API family

chloroquine

form

powder

packaging

pkg of 15 mg

manufacturer/tradename

USP

storage condition

protect from light

color

tan

bp

343.4-347 °F (173—175°C; 845.06°F )

mp

176-215.6 °F (80—102°C)

solubility

chloroform: soluble
dichloromethane: soluble

density

1.14 g/cm³

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

Chloroquine Related Compound D is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Application

Chloroquine Related Compound D USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Chloroquine Phosphate

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1118328

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PHR2438

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Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper

Cheomung A and Na-Bangchang K

Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1031-1040 (2011)

An HPLC method with diode array detector for the simultaneous quantification of chloroquine and desethylchloroquine in plasma and whole blood samples from Plasmodium vivax patients in Vietnam, using quinine as an internal standard

Van Pham T, et al.

Biomedical Chromatography, 30(7), 1104-1111 (2016)

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Vincent MJ, et al.

Virology Journal, 2(1), 1-10 (2005)

Chloroquine Phosphate USP Monograph

USP43-NF38: United States Pharmacopeia and National Formulary

United States Pharmacopeia, 39(3), 959-959 (2020)

Protocols

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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