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Merck
CN

1068004

USP

Betamethasone sodium phosphate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Betamethasone 21-phosphate disodium

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
151-73-5
Molecular Weight:
516.40
NACRES:
NA.24
PubChem Substance ID:
329749107
UNSPSC Code:
41116107
MDL number:
MFCD00200361

Key Documents

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Product Name

Betamethasone sodium phosphate, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

grade

pharmaceutical primary standard

API family

betamethasone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... NR3C1(2908)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Betamethasone sodium phosphate Related Compound reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard and system suitability solution during the assay and identification by using liquid chromatography in conjunction with UV detector according to the given below monographs of United States Pharmacopeia (USP):
  • Dexamethasone Sodium Phosphate
  • Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension
  • Betamethasone Sodium Phosphate
  • Betamethasone Sodium Phosphate Injection

General description

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Betamethasone Sodium Phosphate Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 551-551 (2018)
Dexamethasone Sodium Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(4), 1292-1292 (2020)
Betamethasone Sodium Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 30(4), 549-549 (2020)
Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5), 551-551 (2018)
Betamethasone sodium phosphate.
Nursing times, 100(49), 43-43 (2005-01-06)

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