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1021204

USP

4-Aminophenol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-Hydroxyaniline

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About This Item

Linear Formula:
H2NC6H4OH
CAS Number:
123-30-8
Molecular Weight:
109.13
Beilstein:
385836
MDL number:
MFCD00007869
UNSPSC Code:
41116107
PubChem Substance ID:
329748983
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

paracetamol, acetaminophen, mesalazine

manufacturer/tradename

USP

mp

185-189 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1ccc(O)cc1

InChI

1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

InChI key

PLIKAWJENQZMHA-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.4-Aminophenol is the principal degradation product of acetaminophen, formed as an impurity during its hydrolysis.

Application

This USP reference standard is intended for use in specified quality tests and assays.
Also used to prepare standard and system suitability solutions to test for the presence of 4-aminophenol as an impurity in various pharmaceutical dosage forms of acetaminophen, according to the United States Pharmacopeia (USP) monographs:
  • Mesalamine
  • Acetaminophen Tablets
  • Acetaminophen Oral Suspension
  • Tramadol Hydrochloride and Acetaminophen Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2

Target Organs

Kidney

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Acetaminophen Oral Suspension
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(6), 42-42 (2021)
Mesalamine
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(6), 2800-2800 (2020)
Acetaminophen tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(3), 45-45 (2021)
Tramadol Hydrochloride and Acetaminophen Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(1), 4450-4450 (2017)
Soumabha Bag et al.
Analytica chimica acta, 860, 37-42 (2015-02-16)
Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization. Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested
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