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Merck
CN

PS694

o,p′-DDD

analytical standard

Synonym(s):

1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, (2,4′-Dichlorodiphenyl)dichloroethane, o,p′-DDD, Mitotane

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About This Item

Linear Formula:
(ClC6H4)2CHCHCl2
CAS Number:
Molecular Weight:
320.04
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
200-166-6
Beilstein/REAXYS Number:
2056007
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InChI key

JWBOIMRXGHLCPP-UHFFFAOYSA-N

InChI

1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H

SMILES string

ClC(Cl)C(c1ccc(Cl)cc1)c2ccccc2Cl

grade

analytical standard

packaging

ampule of 250 mg

manufacturer/tradename

Chem Service, Inc. PS-694

Gene Information

rat ... Ar(24208)

pictograms

Health hazard

signalword

Warning

hcodes

pcodes

Hazard Classifications

Carc. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Akira Takeshita et al.
The Journal of endocrinology, 216(3), 297-305 (2012-11-28)
Adrenocortical carcinoma (ACC) is a rare disease with an extremely poor prognosis. Mitotane alone or in combination with other cytotoxic drugs is a common therapeutic option for ACC. In addition to its adrenolytic function, mitotane has been known for decades
Liana Tripto-Shkolnik et al.
The Journal of clinical endocrinology and metabolism, 98(2), 443-447 (2013-01-01)
Adrenocortical carcinoma (ACC) affects patients in a broad age group, including young women. Mitotane, an adrenolytic agent, is the mainstay of treatment after surgical removal of the tumor. There is extreme paucity of information regarding the effect of mitotane on
S Ederhy et al.
Journal of endocrinological investigation, 35(10), 911-914 (2012-09-28)
We designed a single-center retrospective study to assess the QT interval duration and to describe cardio vascular events among patients treated with mitotane for a adrenocortical carcinoma (ACC). We selected 14 patients (6 males and 8 females) that met the
Adrienn Zsippai et al.
Pharmacogenomics, 13(12), 1351-1361 (2012-09-13)
The adrenolytic agent mitotane is widely used in the treatment of adrenocortical cancer; however, its mechanism of action is poorly elucidated. We have studied mitotane-induced mRNA expression changes in the NCI-H295R adrenocortical cancer cell line. Cell viability and hormone assays
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
A Berruti et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23 Suppl 7, vii131-vii138 (2012-11-20)

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