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G006152

LC/MS (TOF) Analysis of 2C Amine Drugs of Abuse on Ascentis® Express HILIC

application for HPLC

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technique(s)

HPLC: suitable

test parameters

column: Ascentis Express HILIC, 5 cm x 2.1 mm I.D., 2.7 μm particles (53934-U)
mobile phase: 2 mM ammonium formate in 90:10 (v:v) acetonitrile:water
flow rate: 0.4 mL/min
pressure: 943 psi (65 bar)
column temp.: 35 °C
detector: TOF/MS
injection: 2 μL
sample: 300 ng/mL in acetonitrile

suitability

application for HPLC

application(s)

forensics and toxicology

Analysis Note

The 2C amines are a family of illicit, psychedelic phenethylamines. The term "2C" refers to the two carbon atoms between the benzene ring and the amino group in the parent molecular structure. A rapid separation of four 2C amine compounds is shown here on an Ascentis Express HILIC column with TOF-MS detection. Cerilliant CRMs were used to ensure reliable MS identification and quantification.

Legal Information

Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

Description
    (R)-(-)-Bromo-DragonFLY hydrochloride solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    2,5-Dimethoxy-4-(n)-propylthiophenethylamine hydrochloride solution, 1.0 mg/mL in acetonitrile: water (9:1) (as free base), ampule of 1 mL, certified reference material, Cerilliant®
    4-Bromo-2,5-dimethoxyphenethylamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
    2C-B-FLY hydrochloride solution, 1 mg/mL in acetonitrile: water (9:1), ampule of 1 mL, certified reference material, Cerilliant®

analytical column

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standard

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