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G006149

UHPLC/MS Analysis of Various Drug Substances on Titan™ C18

application for HPLC

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About This Item

technique(s)

HPLC: suitable

test parameters

column: Titan C18, 5 cm x 2.1 mm I.D., 1.9 μm particles (577122-U)
mobile phase: [A] 5 mM ammonium formate; [B] 5 mM ammonium formate in 90:10 (v:v) acetonitrile:water
gradient: 30 to 70% B in 3.0 min
flow rate: 0.3 mL/min
column temp.: 35 °C
detector: MS/MS
injection: 3 μL
sample: 50 ng/mL in methanol

suitability

application for HPLC

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Analysis Note

A Titan C18 column provided rapid, baseline resolution of this set of drug substances. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.

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Analyte

Description
    Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
    Propranolol hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
    Carbamazepine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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