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G006116

UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18

application for UHPLC

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technique(s)

UHPLC: suitable

test parameters

column: Titan C18 5 cm x 2.1 mm I.D., 1.9 μm particles (577122-U)
mobile phase: [A] 5 mM ammonium acetate in 95:5, water:acetonitrile; [B] 5 mM ammonium acetate in 5:95, water:acetonitrile
gradient: 0 to 100% B in 3 min, held at 100% B for 1 min
flow rate: 0.6 mL/min
pressure: 6770 psi (467 bar)
column temp.: 35 °C
detector: MS-TOF, XIC
injection: 0.5 μL
sample: 1 μg/mL in 95:5, water:methanol

suitability

application for UHPLC

application(s)

forensics and toxicology

Analysis Note

This method shows heroin and related compounds separated on a Titan C18 column and MS detection. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.

Legal Information

Titan is a trademark of Sigma-Aldrich Co. LLC

Analyte

Description
    Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    Procaine hydrochloride, VETRANAL®, analytical standard
    Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    Heroin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
    Alprazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    Papaverine hydrochloride, powder
    Flunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
    Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis
    Noscapine hydrochloride hydrate, analytical standard
    See All (9)

standard

Product No.
Description
Pricing

D9900

Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis

P3510

Papaverine hydrochloride, powder

N9007

Noscapine hydrochloride hydrate, analytical standard

C-006

Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-903

Alprazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

F-907

Flunitrazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-038

Heroin solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

M-005

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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